NFL Week 18 odds, predictions, expert picks: Who will win the AFC North? Can Broncos clinch AFC's top seed?
CBS Sports and SportsLine break down every single NFL game in Week 18
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6 min read
We've reached the end of the road of the 2025 regular season. Week 18 is on our doorstep and there are still loads to figure out as it relates to the overall playoff picture. Division titles are still on the line, as well as important races to determine seeding in both conferences, which sets the stage for a chaotic weekend in the NFL.
While there is plenty of action, Week 18 is also a bit tricky from a gambling perspective, as some teams may opt for rest before entering the postseason, which flips a typical line on its head. But that's where we come in to help.
As we do every week throughout the season, we've collected the best picks and gambling content from CBS Sports and SportsLine in one place. That way, you can get picks against the spread from our CBS Sports experts along with additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let's jump in.
All NFL odds via DraftKings Sportsbook.
Arizona Cardinals at Los Angeles Rams
Sunday, 4:25 p.m. on Fox (Stream: Fubo -- try for free)
Rams -7.5: "There is motivation to be the No. 5 seed this season, as it would send the Rams to either Carolina or Tampa Bay for the wild-card round, as opposed to Chicago or Philadelphia if they are the No. 6 seed. If the 49ers win, however, the Rams will be the No. 6 seed regardless of how their game unfolds, which could result in McVay opting to rest starters. Either way, I still think the Rams will be able to score against Arizona, whether it's Matthew Stafford under center or backup Jimmy Garoppolo. The Cardinals are allowing 28.2 points per game this season, and that number has worsened in recent weeks, as they've surrendered 34.3 points per game over their last three contests. Arizona is also 1-7 ATS over its last eight games entering the regular-season finale." -- CBS Sports NFL writer Tyler Sullivan on why he likes L.A. to cover against Arizona. To see the rest of his Week 18 pick, click here.
Detroit Lions at Chicago Bears
Sunday, 4:25 p.m. on Fox (Stream: Fubo -- try for free)
Bears -3: "The Bears are playing for seeding, while the Lions are looking to vacation spots. The Lions haven't played well down the stretch, while the Bears have on offense. The Lions playing outside have been a different team in recent years, but the Chicago defense is not good right now. This is a shootout, with the Bears taking it." -- CBS Sports Senior NFL analyst Pete Prisco on why he has Chicago defeating the Lions, 31-27. To see all of his Week 18 picks, click here.
Kansas City Chiefs at Las Vegas Raiders
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Chiefs -5.5: "The Raiders need to lose. Yes, they need to lose. If they do, they get the top draft pick. The problem is this version of the Chiefs isn't very good. With Chris Oladokun starting at quarterback, they are still better than the Raiders. Chiefs win it." -- CBS Sports Senior NFL analyst Pete Prisco on why he likes Kansas City to defeat the Raiders. To see all of his Week 18 picks, click here.
Los Angeles Chargers at Denver Broncos
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Broncos -12.5: "It's not just Herbert who needs a week off. The Chargers are also beat up at running back and on the offensive line and at almost every other position. This team needs a week off more than anyone. I realize the Chargers are still playing for seeding, but they're not going to beat anyone in the playoffs if everyone on their roster is hurt, so benching everyone makes sense. On the Broncos' end, they have everything to play for: If Denver pulls off a win here, the Broncos will clinch the No. 1 overall seed in the AFC. So I'm basing my pick off the fact that the Broncos will be extremely motivated and the Chargers will be keeping Herbert on the bench." -- CBS Sports NFL writer John Breech on why he has Denver pulling off the 27-13 win over Los Angeles. To see the rest of his Week 18 picks, click here.
Miami Dolphins at New England Patriots
Sunday, 4:25 p.m. on Fox (Stream: Fubo -- try for free)
Patriots -10.5: "New England still has an opportunity to secure the No. 1 seed in the AFC, provided it defeats the Dolphins and the Chargers are able to beat the Broncos. Both games will be played at the same time, but Denver's path became even easier with L.A. announcing it will rest Justin Herbert, with its playoff position already locked up. Still, I wonder if Mike Vrabel will trot Drake Maye and the starters out for the first half and then check in on the Broncos-Chargers game at halftime. If Trey Lance is surprisingly putting Denver on upset alert, Vrabel will keep his foot on the gas. If that game is out of reach in favor of the Broncos, that would be the point to turn to the reserves.Even under that scenario, the Patriots showed last week that they can put up points in a hurry and build a first-half lead that keeps the backdoor only slightly ajar." -- CBS Sports NFL writer Tyler Sullivan on why he likes New England to cover the double digit spread. To see the rest of his Week 18 picks, click here.
New York Jets at Buffalo Bills
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Bills -7: "The Bills are playing only for seeding, so it will be interesting to see how they handle this one. Do they sit Josh Allen? Does it matter? The Jets are so bad right now that it won't. They are lifeless. Bills take it -- no matter who plays." -- CBS Sports Senior NFL analyst Pete Prisco on why he has Buffalo covering over New York, 27-12. To see all of his Week 18 picks, click here.
Washington Commanders at Philadelphia Eagles
Sunday, 4:25 p.m. on CBS (Stream on Paramount+)
Eagles -7: "The Eagles are playing for the possible No. 2 seed, while the Commanders are playing for nothing. The Eagles beat up on the Commanders two weeks ago, and that will likely be the case here as well. The Eagles need to get the offense going, and this is the perfect tonic for it. Eagles big." -- CBS Sports Senior NFL analyst Pete Prisco on why he has Philly rolling over the Commanders, 29-10. To see all of his Week 18 picks, click here.
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| Commanders at Eagles (-7) |  | | |  | | | |
Baltimore Ravens at Pittsburgh Steelers
Sunday, 8:20 p.m. on NBC (Stream: Fubo -- try for free)
Ravens -3.5: "I'm going down with the ship with the Ravens, who I still think are a good team that has underperformed their talent level, rather than riding with the Steelers, who are not a good team but have somehow wound up in a situation where they will once again finish above .500. If Lamar Jackson is back healthy for this game -- which it seems like the spread expects that he will be -- I simply have to roll with Baltimore given my fundamental beliefs about both teams." -- CBS Sports NFL writer Jared Dubin on why he has Baltimore winning the AFC North, 24-20. To see his top plays for Week 18, click here.
